Lewis - 10th & Cliff, Sioux Falls

Explore This Store
Sioux Falls, SD 57103
Main Phone:
605-367-2000Store Hours
Pharmacy
Pharmacy Phone:
605-367-2310Pharmacy Hours
Your Family Pharmacy
Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.
Stop in at your Sioux Falls Lewis and find a large selection of everyday basics. Take advantage of affordable prices on name brands and specialty items at our convenient location at 10th Street & Cliff Avenue.
Find everything you need plus a few unexpected finds in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.
COVID-19 Vaccine Available
Through a Federal partnership, Lewis Drug is able to give COVID vaccinations in compliance with state guidelines.
Please do not call your local pharmacy to see if they have vaccine.
SD state guidelines: https://doh.sd.gov/Covid/Vacci...
The 10th & Cliff Sioux Falls, SD Lewis Drug is now offering the COVID-19 vaccine. Click the link below to see if there are any appointments available.