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Lewis - 10th & Cliff, Sioux Falls

1301 E 10th St. , Sioux Falls, SD 57103
lewis drug sunny exterior

Explore This Store

1301 E 10th St.
Sioux Falls, SD 57103

Main Phone:

605-367-2000

Store Hours


Mon: 8:00am - 9:00pm
Tue: 8:00am - 9:00pm
Wed: 8:00am - 9:00pm
Thu: 8:00am - 9:00pm
Fri: 8:00am - 9:00pm
Sat: 8:00am - 9:00pm
Sun: 8:00am - 6:00pm
Weekly Ad Directions

Pharmacy

Pharmacy Phone:

605-367-2310

Pharmacy Hours


Mon: 9am - 8pm
Tue: 9am - 8pm
Wed: 9am - 8pm
Thu: 9am - 8pm
Fri: 9am - 8pm
Sat: 9am - 6pm
Sun: 10am - 6pm

Your Family Pharmacy

Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.

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COVID-19 VACCINE AVAILABLE

The 10th & Cliff, Sioux Falls, SD Lewis store offers Covid-19 vaccine.

Walk-in appointments are welcome Monday thru Friday.

Mon: 10am - 6pm
Tues: 10am - 6pm
Wed: 10am - 6pm
Thur: 10am - 6pm
Fri: 10am - 6pm

Call (605) 367-2310 for Saturday & Sunday availability.

Call Now

Stop in at your Sioux Falls Lewis and find a large selection of everyday basics. Take advantage of affordable prices on name brands and specialty items at our convenient location at 10th Street & Cliff Avenue.

Find everything you need plus a few unexpected finds in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

Upcoming Events

October Senior Citizen's Week

Shop & save 10%
October 1, 2023
All Day

Brookings Vaccination Clinic

Be Prepared This Season!
October 4, 2023
9:00 am

Sioux Falls Vaccination Clinic 1

Be Prepared This Season!
October 5, 2023
9:00 am

Sioux Falls Vaccination Clinic 2

Be Prepared This Season!
October 10, 2023
4:30 pm

Madison Vaccination Clinic

Be Prepared This Season!
October 11, 2023
9:00 am
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