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About

Your first stop for over 79 years.

Since 1942, shoppers have trusted family-owned Lewis as their neighborhood store and pharmacy. With 57 stores conveniently located throughout South Dakota, Iowa and Minnesota! In addition to quality prescription and non-prescription drugs, Lewis has a huge selection of everyday basics, plus name brands and specialty items—always at affordable prices.

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Looking Back: Lewis Drug

On Feb. 10, 1942, South Dakota’s first self-service drugstore opened at 309 S. Phillips Ave. It was a little store called Lewis, and it occupied the space now run by CH Patisserie just south of Minerva’s.

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