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Lewis Family Drug - De Smet

111 Calumet Ave. SW, De Smet, SD 57231

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111 Calumet Ave. SW
De Smet, SD 57231

Main Phone:


Store Hours

Mon: 8:30am - 5:30pm
Tue: 8:30am - 5:30pm
Wed: 8:30am - 5:30pm
Thu: 8:30am - 5:30pm
Fri: 8:30am - 5:30pm
Sat: 9am - 12pm
Sun: Closed
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Your Family Pharmacy

Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.

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The DeSmet, SD Lewis Family Drug is now offering COVID-19 vaccine.

Vaccination appointments are available Monday thru Friday.

Call (605) 854-9033 to schedule your appointment.


Stop by your local Lewis Family Drug, conveniently located in De Smet, and find a large selection everyday essentials, all at affordable prices.

Need to order a prescription? Give our pharmacy a call or quickly and safely refill your prescription with Online or Mobile Refills.

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