Get the latest offers and updates from Lewis.

Sign up to receive email alerts on Lewis weekly ads, coupons, in-store events and more.

#15 Lewis Ellis Sioux Falls

2525 S. Ellis Road, Sioux Falls, SD 57106

Explore This Store

2525 S. Ellis Road
Sioux Falls, SD 57106

Main Phone:

605-367-2000

Store Hours


Mon: 8am - 9pm
Tue: 8am - 9pm
Wed: 8am - 9pm
Thu: 8am - 9pm
Fri: 8am - 9pm
Sat: 8am - 9pm
Sun: 8am - 9pm
Weekly Ad Directions

Pharmacy

Pharmacy Phone:

605-367-2410

Pharmacy Hours


Mon: 8am - 9pm​
Tue: 8am - 9pm​
Wed: 8am - 9pm​
Thu: 8am - 9pm​
Fri: 8am - 9pm​
Sat: 8am - 9pm​
Sun: 8am - 9pm​

Your Family Pharmacy

Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.

View More

COVID-19 VACCINE AVAILABLE

The Lewis Drug at 32nd & Ellis Rd. in Sioux Falls, SD offers the COVID-19 Vaccine.

Vaccine Clinic Hours:

Walk-ins are welcome Monday - Friday.

Mon: 10am - 6pm
Tues: 10am - 6pm
Wed: 10am - 6pm
Thur: 10am - 6pm
Fri: 10am - 6pm

(605)367-2410 Call for Saturday and Sunday availability.

Call Now

Stop by your Sioux Falls Lewis on Ellis Road and find a huge selection of home essentials and everyday basics. Plus find great prices on name brands and specialty items.

Whether you’ve run out of supplies or you’re looking to discover something new, you'll find everything on your list in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

Upcoming Events

Get the latest offers and updates from Lewis.