Get the latest offers and updates from Lewis.

Sign up to receive email alerts on Lewis weekly ads, coupons, in-store events and more.

Lewis - 26th & Sycamore, Sioux Falls

4409 E. 26th St., Sioux Falls, SD 57103

Explore This Store

4409 E. 26th St.
Sioux Falls, SD 57103

Main Phone:

605-367-2000

Store Hours


Mon: 8am - 9pm
Tue: 8am - 9pm
Wed: 8am - 9pm
Thu: 8am - 9pm
Fri: 8am - 9pm
Sat: 8am - 9pm
Sun: 8am - 9pm
Weekly Ad Directions

Pharmacy

Pharmacy Phone:

605-367-2710

Pharmacy Hours


Mon: 8am - 9pm​
Tue: 8am - 9pm​
Wed: 8am - 9pm​
Thu: 8am - 9pm​
Fri: 8am - 9pm​
Sat: 8am - 9pm​
Sun: 8am - 9pm​

Your Family Pharmacy

Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.

View More

Make Lewis your first stop for your everyday essentials! Our convenient store at 26th Street & Sycamore Avenue offers a wide selection of name brands and specialty items, always at affordable prices.

You'll find everything on your shopping list along with unexpected treasures in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

COVID-19 Vaccine Available

Through a Federal partnership, Lewis Drug is able to give COVID vaccinations in compliance with state guidelines.

Please do not call your local pharmacy to see if they have vaccine.

SD state guidelines: https://doh.sd.gov/Covid/Vacci...

The 26th & Sycamore, SD Lewis Drug is now offering the COVID-19 vaccine. Click the link below to see if there are any appointments available.

SCHEDULE AN APPOINTMENT

Upcoming Events

Get the latest offers and updates from Lewis.