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Lewis - 26th & Sycamore, Sioux Falls

4409 E. 26th St., Sioux Falls, SD 57103

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4409 E. 26th St.
Sioux Falls, SD 57103

Main Phone:


Store Hours

Mon: 8am - 9pm
Tue: 8am - 9pm
Wed: 8am - 9pm
Thu: 8am - 9pm
Fri: 8am - 9pm
Sat: 8am - 9pm
Sun: 8am - 9pm
Weekly Ad Directions


Pharmacy Phone:


Pharmacy Hours

Mon: 8am - 9pm​
Tue: 8am - 9pm​
Wed: 8am - 9pm​
Thu: 8am - 9pm​
Fri: 8am - 9pm​
Sat: 8am - 9pm​
Sun: 8am - 9pm​

Your Family Pharmacy

Trusted for decades, ready for the future. Every Lewis pharmacy provides fast and friendly service, from prescription refills to vaccine shots and beyond.

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The 26th & Sycamore Lewis in Sioux Falls, SD offers the COVID-19 Vaccine.


Walk-in appointments are welcome Monday thru Friday.

Mon: 10am - 6pm
Tues: 10am - 6pm
Wed: 10am - 6pm
Thur: 10am - 6pm
Fri: 10am - 6pm

Call (605) 367-2710 for Saturday & Sunday availability.

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Make Lewis your first stop for your everyday essentials! Our convenient store at 26th Street & Sycamore Avenue offers a wide selection of name brands and specialty items, always at affordable prices.

You'll find everything on your shopping list along with unexpected treasures in departments like Health & Beauty, Grocery, Pets, Wine & Spirits, Lawn & Garden and more.

Upcoming Events

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